In pathology, the high contrast imaging provided by a LVEM is a major advantage. Electron microscopy is a powerful diagnostic tool used to assist in the diagnosis of diseases such as: Kidney disease, muscle disorders, neurological disorders, ciliary dysfunction, viral gastroenteritis, viral infections and other disorders. Electron microscopy in general allows for the study of the activities, functions, properties and organization of cells and the analysis of fine structures of a biopsy.

Electron microscopy approaches complement light microscopy by providing greater detail. Transmission electron microscopes (TEM) use electrons to image tissues at much greater magnification than is possible using photons in a light microscope, allowing us to visualize in detail the many structures and organelles within cells. Electron microscopy is the only method to provide images for analysis of ultrastructural pathologic changes in various tissues.

Electron microscopy traditionally is one of the most demanding techniques to learn. However the LVEM5 and LVEM25 are simple enough to operate and maintain that even a non-microscopist can produce high quality images. Conventional TEMs are often very large and costly tools, limiting the accessibility and sample throughput volume. This is not the case with the benchtop design, low facilities requirements and low cost of the LVEM tools.

The LVEM microscopes provide high contrast results that are acquired from samples in their inherent, natural state, yet still allow for staining as an option. Although there are instances where staining is desirable for diagnostic purposes, the necessity to stain samples in order to generate adequate detailed contrast cannot be viewed as advantageous. 

The LVEM25 is built upon the same platform as the LVEM5 and has the added benefit of being able to work with conventionally prepared thin sectioned materials, making it a true low-cost replacement for conventional full sized EMs.

Recently, a thorough clinical validation exercise was performed comparing the diagnostic utility of images obtained on a conventional TEM and compact TEM, in the appropriately titled report “Clinical Validation of Low-Voltage “Compact” Transmission Electron Microscopy for Ultrastructural Evaluation of Kidney and Heart Biopsy Samples” (Lawrence, et al., 2020). Lawrence and co-authors concluded that “Compact TEM is a clinically valid means of ultrastructural evaluation of renal and cardiac biopsy specimens,” and “Compact TEM maintains comparable ability to discriminate key diagnostic findings in these samples.”

Whether it's in the fields of pathology or other life sciences, researchers and medical professionals are assured of top notch imaging with LVEM microscopes.


LVEM5 Benchtop Electron Microscope


LVEM25 Electron Microscope


LVEM 25E Electron Microscope

Contact Us

Interested in learning more about our family of low voltage electron microscopes?